HAVCR1 Antikörper (AA 289-307)

Produktnummer ABIN3031182

Der Kaninchen Polyklonal anti-HAVCR1 Antikörper (ABIN3031182) detektiert spezifisch HAVCR1 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für HAVCR1 Antikörper (AA 289-307) (ABIN3031182)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAVCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HAVCR1 Antikörper

Bindungsspezifität: AA 289-307

Verwendungszweck: TIM-1 Antibody / KIM-1

Aufreinigung: Antigen affinity

Immunogen: Amino acids 289-307 (HPRAEDNIYIIEDRSRGAE-rat) were used as the immunogen for this TIM-1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Titration of the TIM-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized TIM-1 antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Andere Bezeichnung: TIM-1

Substanzklasse: Virus

Hintergrund: TIM-1 antibody targets T cell immunoglobulin and mucin domain containing protein 1, also widely known as Kidney injury molecule 1 (KIM-1) and encoded by the HAVCR1 gene. TIM-1 is a type I transmembrane glycoprotein with an extracellular immunoglobulin V-like domain and a mucin-rich region, localized primarily to the plasma membrane. Under normal physiological conditions, TIM-1 expression in kidney tissue is low, but it is strongly induced in proximal tubular epithelial cells following renal injury, making it a well-established marker of kidney damage.

Functionally, T cell immunoglobulin and mucin domain containing protein 1 participates in epithelial cell injury responses, phagocytosis of apoptotic debris, and immune modulation. TIM-1 has been shown to act as a scavenger receptor that recognizes phosphatidylserine on apoptotic cells, facilitating clearance and tissue repair processes. In immune cells, TIM-1 can influence T cell activation and cytokine production, linking tissue injury signals with immune regulation. A TIM-1 antibody supports studies focused on renal injury mechanisms and immune signaling.

TIM-1 expression is most prominently associated with injured kidney epithelium, but it is also detected in activated immune cells, including subsets of T lymphocytes. Its inducible expression pattern reflects a role in sensing cellular stress and damage rather than maintaining baseline tissue function. TIM-1 can interact with multiple ligands and signaling partners, enabling it to participate in pathways that regulate inflammation, tissue remodeling, and immune responses following injury.

From a disease-relevance perspective, TIM-1, also referred to as KIM-1, is extensively studied as a biomarker for acute kidney injury and chronic kidney disease. Elevated TIM-1 expression correlates with tubular damage and disease severity, and it has been investigated in toxicological studies, ischemia-reperfusion injury, and drug-induced nephrotoxicity. Beyond renal disease, TIM-1 has also been explored in inflammatory disorders and cancer biology, where its immune regulatory functions may contribute to disease progression.

At the molecular level, T cell immunoglobulin and mucin domain containing protein 1 contains conserved structural domains that support ligand binding and signal transduction. Glycosylation of the mucin domain can influence apparent migration behavior on SDS-PAGE without implying changes in primary sequence. TIM-1 antibody reagents support research applications focused on kidney injury, epithelial stress responses, and immune regulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: O54947