DPYD Antikörper (AA 33-52)

Produktnummer ABIN3030731

Der Kaninchen Polyklonal Anti-DPYD-Antikörper wurde für WB validiert. Er ist geeignet, DPYD in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für DPYD Antikörper (AA 33-52) (ABIN3030731)

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPYD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DPYD Antikörper

Bindungsspezifität: AA 33-52

Aufreinigung: Antigen affinity

Immunogen: Amino acids 33-52 (AKKLDKKHWKRNPDKNCFNC-human) were used as the immunogen for this DPYD antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the DPYD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the DPYD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu DPYD

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Andere Bezeichnung: DPYD

Hintergrund: Dihydropyrimidine Dehydrogenase, also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the gene was mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the gene is mapped to 1p22. The highest level of DPYD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity could be detected in erythrocytes. The activity of DPYD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process