Desmoglein 3 Antikörper (AA 981-999)

Produktnummer ABIN3030722

Der Kaninchen Polyklonal Anti-Desmoglein 3-Antikörper wurde für WB validiert. Er ist geeignet, Desmoglein 3 in Proben von Human zu detektieren.

Kurzübersicht für Desmoglein 3 Antikörper (AA 981-999) (ABIN3030722)

Target: Desmoglein 3 (DSG3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmoglein 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Desmoglein 3 Antikörper

Bindungsspezifität: AA 981-999

Aufreinigung: Antigen affinity

Immunogen: Amino acids 981-999 (QLRGSHTMLCTEDPCSRLI-human ) were used as the immunogen for this Desmoglein 3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Desmoglein 3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Desmoglein 3

Target: Desmoglein 3 (DSG3)

Andere Bezeichnung: Desmoglein 3

Hintergrund: Desmoglein 3 is also known as PVA (Pemphigus Vulgaris Antigen). Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens two different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or Desmoglein 3) in the case of PV and Desmoglein 1 in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering.

UniProt: P32926