MCTS1 Antikörper

Produktnummer ABIN303009

Produktdetails anti-MCTS1 Antikörper

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCTS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody residues 3-14[KKFDEKENVSNC] of the 20 kDa MCT-1 protein.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 20 μg/mL. Western Blot: 1: 500 - 1: 1000. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu MCTS1

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Andere Bezeichnung: MCTS1 (MCTS1 Produkte)

Synonyme: MCT-1 antikoerper, MCT1 antikoerper, MCT1a antikoerper, cb517 antikoerper, zgc:55682 antikoerper, 1500019M23Rik antikoerper, zgc:56242 antikoerper, mcts1 antikoerper, MGC89874 antikoerper, MCTS1 antikoerper, MCT-1A antikoerper, mct-1 antikoerper, mct1 antikoerper, MCT-1B antikoerper, mcts1-a antikoerper, mcts1-b antikoerper, MCTS1, re-initiation and release factor antikoerper, solute carrier family 16 (monocarboxylate transporter), member 1b antikoerper, malignant T cell amplified sequence 1 antikoerper, malignant T-cell amplified sequence 1 antikoerper, solute carrier family 16 member 1 antikoerper, malignant T-cell amplified sequence 1 S homeolog antikoerper, monocarboxylate transporter 1 antikoerper, malignant T-cell amplified sequence 1 L homeolog antikoerper, MCTS1 antikoerper, slc16a1b antikoerper, Mcts1 antikoerper, mcts1 antikoerper, SLC16A1 antikoerper, mcts1.S antikoerper, MCT1 antikoerper, mcts1.L antikoerper

Hintergrund: Malignant T cell amplified sequence 1 (MCTS1) is an anti-oncogene that plays a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer, and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.Synonyms: MCT-1, MCT1, MCTS1, Malignant T cell amplified sequence 1

Gen-ID: 28985

NCBI Accession: NP_001131026

UniProt: Q9ULC4