Aryl Hydrocarbon Receptor Antikörper (AA 832-848)

Produktnummer ABIN3030027

Der Kaninchen Polyklonal anti-Aryl Hydrocarbon Receptor Antikörper (ABIN3030027) detektiert spezifisch Aryl Hydrocarbon Receptor in WB, IF, IHC (p) und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Aryl Hydrocarbon Receptor Antikörper (AA 832-848) (ABIN3030027)

Target: Aryl Hydrocarbon Receptor (AHR)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aryl Hydrocarbon Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-Aryl Hydrocarbon Receptor Antikörper

Bindungsspezifität: AA 832-848

Verwendungszweck: Aryl hydrocarbon Receptor Antibody / AHR

Aufreinigung: Antigen affinity

Immunogen: Amino acids 832-848 (HPSEARPFPDLTSSGFL-human) were used as the immunogen for this Aryl hydrocarbon Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Aryl hydrocarbon Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Aryl hydrocarbon Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Aryl Hydrocarbon Receptor

Target: Aryl Hydrocarbon Receptor (AHR)

Andere Bezeichnung: Aryl hydrocarbon Receptor

Hintergrund: Aryl hydrocarbon receptor, also called AHR and bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. It is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr-/- or Er-alpha -/- ovariectomized mice. CD4-positive cells from mice lacking the recepter developed Th17 responses but failed to produce IL-22 and did not show enhanced Th17 development. Activation of Aryl hydrocarbon receptor during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in -/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

UniProt: P35869

Pathways: Regulation of Cell Size