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IDO Antikörper (N-Term)

IDO Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3029730
  • Target Alle IDO Antikörper anzeigen
    IDO (Indoleamine 2,3-Dioxygenase (IDO))
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 18
    • 5
    • 1
    Human
    Wirt
    • 10
    • 10
    • 4
    Kaninchen
    Klonalität
    • 13
    • 10
    Polyklonal
    Konjugat
    • 15
    • 5
    • 2
    • 1
    • 1
    Dieser IDO Antikörper ist unkonjugiert
    Applikation
    • 20
    • 16
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of human Indoleamine 2, 3-dioxygenase (MAHAMENSWTISKEYHIDEE) was used as the immunogen for this IDO antibody.
    Isotyp
    IgG
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  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the IDO antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the IDO antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    IDO (Indoleamine 2,3-Dioxygenase (IDO))
    Andere Bezeichnung
    IDO Indoleamine 2, 3-Dioxygenase (IDO Produkte)
    Synonyme
    IDO antikoerper, IDO-1 antikoerper, INDO antikoerper, Ido antikoerper, Indo antikoerper, indoleamine 2,3-dioxygenase 1 antikoerper, IDO1 antikoerper, Ido1 antikoerper
    Hintergrund
    Indoleamine 2,3-dioxygenase, also called INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. IDO-Interferon-gamma interaction has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
    UniProt
    P14902
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