This mAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80 % of all cases, and small cell, which accounts for roughly 20 % of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.
Aufreinigung
Protein G affinity chromatography
Immunogen
Lung Cancer-associated antigen isolated from small cell lung carcinoma-derived cell line was used as the immunogen for the SCLC Marker antibody.
Reaktivität: Human
IF, ICC
Wirt: Maus
Monoclonal
MOC-52
Biotin
Applikationshinweise
Optimal dilution of the SCLC Marker antibody should be determined by the researcher.\. Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (Frozen): 0.5-1.0 μg/mL for 30 minutes at RT
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store the SCLC Marker antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Target
Small Cell Lung Cancer (SCLC)
Andere Bezeichnung
SCLC Marker
Hintergrund
This mAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80 % of all cases, and small cell, which accounts for roughly 20 % of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.