TGF-beta Antikörper

Produktnummer ABIN3023878

Der Maus Monoklonal anti-TGF-beta Antikörper (Klon 1D11-16-8) (ABIN3023878) detektiert spezifisch TGF-beta in WB, Neut, ELISA, Func und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für TGF-beta Antikörper (ABIN3023878)

Target: TGF-beta (TGFb)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGF-beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Neutralization (Neut), ELISA, Functional Studies (Func), Immunofluorescence (IF)

Güteklasse: Carrier-free

Klon: 1D11-16-8

Produktdetails anti-TGF-beta Antikörper

Verwendungszweck: TGF-beta Antibody (1/2/3) (azide and preservative free)

Produktmerkmale: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Aufreinigung: Protein G affinity chromatography

Immunogen: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TGF-beta antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the TGF-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu TGF-beta

Target: TGF-beta (TGFb)

Andere Bezeichnung: TGF-beta

Hintergrund: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus