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SOX2 Antikörper (AA 1-140)

Der Kaninchen Polyklonal Anti-SOX2-Antikörper wurde für WB, IHC, IF und IP validiert. Er ist geeignet, SOX2 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN3021003

Kurzübersicht für SOX2 Antikörper (AA 1-140) (ABIN3021003)

Target

Alle SOX2 Antikörper anzeigen
SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Reaktivität

  • 246
  • 140
  • 73
  • 21
  • 13
  • 11
  • 10
  • 10
  • 8
  • 8
  • 7
  • 7
  • 5
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 185
  • 70
  • 2
Kaninchen

Klonalität

  • 162
  • 95
Polyklonal

Konjugat

  • 122
  • 14
  • 14
  • 10
  • 6
  • 6
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
Dieser SOX2 Antikörper ist unkonjugiert

Applikation

  • 165
  • 99
  • 92
  • 49
  • 44
  • 42
  • 40
  • 40
  • 30
  • 24
  • 22
  • 20
  • 16
  • 12
  • 4
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
  • Bindungsspezifität

    • 60
    • 16
    • 16
    • 15
    • 15
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-140

    Sequenz

    MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SOX2 (NP_003097.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.01% thiomersal,50% glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid freeze / thaw cycles

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Yuan, Liu, Yu, Yin, Peng, Gao, Zhu, Cao, Yang, Fan, Li: "FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness." in: Cell death & disease, Vol. 9, Issue 5, pp. 562, (2018) (PubMed).

    Hu, Xia, Wu, Li, Qi, Hu, Wei, Li, Tian, Wei, Shen, Yin, Jiang, Yuan, Qiang, Han, Peng: "NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma." in: Oncogene, Vol. 36, Issue 33, pp. 4706-4718, (2017) (PubMed).

  • Target

    SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

    Andere Bezeichnung

    SOX2

    Hintergrund

    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).,ANOP3,MCOPS3,SOX2,SRY-box 2,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Cell Biology & Developmental Biology,ESC Pluripotency and Differentiation,Neuroscience,Cell Type Marker,Stem Cells,Embryonic Stem Cells,Germline Stem Cells,Neural Stem Cell marker,SOX2

    Molekulargewicht

    34 kDa

    Gen-ID

    6657

    UniProt

    P48431

    Pathways

    Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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