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DAXX Antikörper (AA 580-740)

Dieses Anti-DAXX-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von DAXX in WB, ICC und IP. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN302079

Kurzübersicht für DAXX Antikörper (AA 580-740) (ABIN302079)

Target

Alle DAXX Antikörper anzeigen
DAXX (Death-Domain Associated Protein (DAXX))

Reaktivität

  • 159
  • 62
  • 51
  • 7
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 143
  • 17
Maus

Klonalität

  • 132
  • 28
Monoklonal

Konjugat

  • 62
  • 7
  • 7
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
Dieser DAXX Antikörper ist unkonjugiert

Applikation

  • 131
  • 65
  • 65
  • 38
  • 37
  • 25
  • 21
  • 20
  • 16
  • 14
  • 6
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Klon

DAXX-03
  • Bindungsspezifität

    • 23
    • 21
    • 16
    • 16
    • 15
    • 9
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 580-740

    Verwendungszweck

    Anti-DAXX Purified

    Spezifität

    The mouse monoclonal antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    His6-tagged protein corresponding to amino acids 580-740 of human Daxx.

    Isotyp

    IgG1
  • Applikationshinweise

    Western blotting: Recommended dilution: 2 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

  • Target

    DAXX (Death-Domain Associated Protein (DAXX))

    Andere Bezeichnung

    DAXX

    Hintergrund

    Death domain associated protein,Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).,DAP6, EAP1, BING2

    Gen-ID

    1616

    UniProt

    Q9UER7

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway
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