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HLA-DR1 Antikörper (PE)

HLA-DR1 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-267 PE
Produktnummer ABIN302033
  • Target Alle HLA-DR1 Produkte
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Reaktivität
    Human
    Wirt
    • 2
    Maus
    Klonalität
    • 2
    Monoklonal
    Konjugat
    • 1
    • 1
    Dieser HLA-DR1 Antikörper ist konjugiert mit PE
    Applikation
    • 2
    • 2
    • 2
    Flow Cytometry (FACS)
    Spezifität
    The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
    Klon
    MEM-267
    Isotyp
    IgG2b
  • Applikationshinweise
    Flow cytometry: The antibody MEM-267 stains immature dendritic cells that express empty cell surface MHC molecules, but not cells that express predominantly peptide loaded forms. Recommended dilution: 1-5 μg/mL.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Target
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Andere Bezeichnung
    HLA-DR1 (HLA-DR1 Produkte)
    Hintergrund
    HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
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