GPX4 Antikörper (AA 30-197)

Produktnummer ABIN3015730

Dieses Anti-GPX4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GPX4 in WB, IHC, IF und IP. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GPX4 Antikörper (AA 30-197) (ABIN3015730)

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPX4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-GPX4 Antikörper

Bindungsspezifität: AA 30-197

Sequenz: ASRDDWRCAR SMHEFSAKDI DGHMVNLDKY RGFVCIVTNV ASQUGKTEVN YTQLVDLHAR YAECGLRILA FPCNQFGKQE PGSNEEIKEF AAGYNVKFDM FSKICVNGDD AHPLWKWMKI QPKGKGILGN AIKWNFTKFL IDKNGCVVKR YGPMEEPLVI EKDLPHYF

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-197 of human GPX4 (NP_002076.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-GPX4 Antikörper (ABIN3015730)

Wang, Zheng, Zhang, Zhao, Wang, Wang, Shang, Barasch, Qiu: "Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury." in: American journal of physiology. Renal physiology, Vol. 315, Issue 4, pp. F1042-F1057, (2018) (PubMed).

Details zu GPX4

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Andere Bezeichnung: GPX4

Hintergrund: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development, thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.,GPX4,GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,GPX4

Molekulargewicht: 19 kDa/22 kDa

Gen-ID: 2879

UniProt: P36969