Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ITGA4 Antikörper

This anti-ITGA4 antibody (ABIN2967175) is a Mouse Monoclonal antibody detecting ITGA4 in FACS, IHC (fro), Func. Suitable for Human, Cow, Dog, Horse, Cat, Sheep, Non-Human Primate.
Produktnummer ABIN2967175

Kurzübersicht für ITGA4 Antikörper (ABIN2967175)

Target

Alle ITGA4 Antikörper anzeigen
ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität

  • 141
  • 78
  • 32
  • 10
  • 10
  • 9
  • 8
  • 7
  • 6
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Non-Human Primate

Wirt

  • 76
  • 63
  • 40
Maus

Klonalität

  • 118
  • 62
  • 2
Monoklonal

Konjugat

  • 95
  • 15
  • 14
  • 13
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser ITGA4 Antikörper ist unkonjugiert

Applikation

  • 95
  • 52
  • 52
  • 42
  • 40
  • 23
  • 15
  • 10
  • 8
  • 6
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Klon

9F10
  • Verwendungszweck

    Anti-Hu CD49d Purified Low Endotoxin

    Spezifität

    The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.

    Kreuzreaktivität (Details)

    Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Endotoxin-Niveau

    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Functional application: In vitro T cell costimulation.
    Flow cytometry: Recommended dilution: 1-4 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Target

    ITGA4 (Integrin alpha 4 (ITGA4))

    Andere Bezeichnung

    CD49d

    Hintergrund

    Integrin subunit alpha 4,CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.,ITGA4, VLA-4 alpha

    Gen-ID

    3676

    UniProt

    P13612

    Pathways

    Integrin Complex
Sie sind hier:
Chat with us!