ITGA4 Antikörper

Produktnummer ABIN2967175

Dieses Anti-ITGA4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ITGA4 in FACS, IHC (fro) und Func. Geeignet für Human, Rind (Kuh), Hund, Pferd, Cat, Schaf und Non-Human Primate.

Kurzübersicht für ITGA4 Antikörper (ABIN2967175)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Klon: 9F10

Produktdetails anti-ITGA4 Antikörper

Verwendungszweck: Anti-Hu CD49d Purified Low Endotoxin

Spezifität: The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.

Kreuzreaktivität (Details): Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Endotoxin-Niveau: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Functional application: In vitro T cell costimulation.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: CD49d

Hintergrund: Integrin subunit alpha 4,CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.,ITGA4, VLA-4 alpha

Gen-ID: 3676

UniProt: P13612

Pathways: Integrin Complex