FKBP4 Antikörper (full length, N-Term)

Produktnummer ABIN2962775

Produktdetails anti-FKBP4 Antikörper

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Bindungsspezifität: full length, N-Term

Reaktivität: Human, Maus, Ratte, Hamster, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FKBP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Spezifität: Reacts with human FKBP52. Cross-reacts with mouse, rat, canine and hamster protein.

Aufreinigung: Purified (protein G)

Immunogen: Recombinant full-length FKBP52 with an N-terminal polyhistidine tag.

Klon: Hi52C

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
FC(1-2 μg for 10.6 cells) IHC(4 - 5 μg/mL) WB(0.5 - 1 μg/mL)

Positive control: HeLa cell lysate, rat kidney and rat/mouse testes tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, glycerol 50 % .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Dilute in PBS or medium that is identical to that used in the assay system.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Andere Bezeichnung: FKBP52 (FKBP4 Produkte)

Synonyme: HBI antikoerper, p52 antikoerper, hsp56 antikoerper, PPIase antikoerper, fkbp52 antikoerper, fkbp59 antikoerper, MGC81078 antikoerper, wu:fb34f09 antikoerper, 59kDa antikoerper, AL022792 antikoerper, AW208983 antikoerper, FKBP-4 antikoerper, FKBP-52 antikoerper, FKBP52 antikoerper, FKPB52 antikoerper, p59 antikoerper, FKBP51 antikoerper, FKBP59 antikoerper, Hsp56 antikoerper, P59 antikoerper, FK506 binding protein 4 antikoerper, FK506 binding protein 4 S homeolog antikoerper, FKBP4 antikoerper, fkbp4.S antikoerper, fkbp4 antikoerper, Fkbp4 antikoerper

Hintergrund: FK506-binding proteins, FKBP51 and FKBP52, are high molecular weight immunophilins that are part of the mature glucocorticoid receptor heterocomplex. The N-terminal domains of these proteins bind FK506 and have peptidyl-prolyl isomerase activity that converts prolyl peptide bonds within target proteins from cis- to transproline. The C-terminal domains contain the tetratricopeptide repeats that are involved in protein-protein interactions with Hsp90. Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptors differently and have different Hsp90-binding characteristics. In addition, FKBP51 is linked to the progesterone receptor while FKBP52 is linked to progesterone, androgen, and glucocorticoid receptors.

Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4 51 kDa FK506-binding protein, FKBP51 52 kDa FK506-binding protein, FKBP-52 59 kDa immunophilin, p59 FK506-binding protein 4, FKBP-4 FKBP59 HSP-binding immunophilin, HBI Immunophilin FKBP52 Rotamase Gene name : FKBP4

Gen-ID: 2288

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway