FKBP4 Antikörper (full length, N-Term)

Produktnummer ABIN2962775

Dieser Anti-FKBP4 Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von FKBP4 in WB, IHC, IP, ICC und FACS. Geeignet für Human, Maus, Ratte, Hamster und Hund.

Kurzübersicht für FKBP4 Antikörper (full length, N-Term) (ABIN2962775)

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reaktivität: Human, Maus, Ratte, Hamster, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FKBP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: Hi52C

Produktdetails anti-FKBP4 Antikörper

Bindungsspezifität: full length, N-Term

Spezifität: Reacts with human FKBP52. Cross-reacts with mouse, rat, canine and hamster protein.

Aufreinigung: Purified (protein G)

Immunogen: Recombinant full-length FKBP52 with an N-terminal polyhistidine tag.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
FC(1-2 μg for 10.6 cells) IHC(4 - 5 μg/mL) WB(0.5 - 1 μg/mL)

Positive control: HeLa cell lysate, rat kidney and rat/mouse testes tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, glycerol 50 % .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Dilute in PBS or medium that is identical to that used in the assay system.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Andere Bezeichnung: FKBP52

Hintergrund: FK506-binding proteins, FKBP51 and FKBP52, are high molecular weight immunophilins that are part of the mature glucocorticoid receptor heterocomplex. The N-terminal domains of these proteins bind FK506 and have peptidyl-prolyl isomerase activity that converts prolyl peptide bonds within target proteins from cis- to transproline. The C-terminal domains contain the tetratricopeptide repeats that are involved in protein-protein interactions with Hsp90. Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptors differently and have different Hsp90-binding characteristics. In addition, FKBP51 is linked to the progesterone receptor while FKBP52 is linked to progesterone, androgen, and glucocorticoid receptors.

Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4 51 kDa FK506-binding protein, FKBP51 52 kDa FK506-binding protein, FKBP-52 59 kDa immunophilin, p59 FK506-binding protein 4, FKBP-4 FKBP59 HSP-binding immunophilin, HBI Immunophilin FKBP52 Rotamase Gene name : FKBP4

Gen-ID: 2288

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway