UVRAG Antikörper (Biotin)
Kurzübersicht für UVRAG Antikörper (Biotin) (ABIN2868821)
Target
Alle UVRAG Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Spezifität
- Predicted molecular weight at ~78.1 kDa. Observed molecular weights in the 75-90 kDa range.
-
Kreuzreaktivität
- Human, Maus, Ratte
-
Aufreinigung
- Peptide Affinity Purified
-
Immunogen
- Synthetic peptide from the mid-protein of human UVRAG
-
-
-
-
Applikationshinweise
-
- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
-
Kommentare
-
A 1:1000 dilution of ABIN2868821 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
-
-
- UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
-
Andere Bezeichnung
- UVRAG
-
Hintergrund
- UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
-
Gen-ID
- 7405
-
NCBI Accession
- NP_003360
-
UniProt
- Q9P2Y5
Target
-