Phospholamban Antikörper (phosphospecific)

Produktnummer ABIN285884

Der Kaninchen Polyklonal Anti-Phospholamban-Antikörper wurde für WB validiert. Er ist geeignet, Phospholamban in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Phospholamban Antikörper (phosphospecific) (ABIN285884)

Target: Phospholamban (PLN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Phospholamban Antikörper

Bindungsspezifität: AA 14-25, phosphospecific

Kreuzreaktivität: Rind (Kuh), Hund, Maus, Ratte (Rattus)

Kreuzreaktivität (Details): Bovine, Predicted to cross-react with human, mouse, rat, rabbit, pig and dog.1 mg/ml

Aufreinigung: Protein A affinity chromatography

Immunogen: Phospho-Phospholamban antibody was raised in rabbit using a synthetic peptide conjugated to KLH, corresponding to amino acids 14-25 of human cardiac phospholamban (RA[pS]TIEMPQQAR-C) as the immunogen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined byt he investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 100 mM Tris-glycine, pH 7.4, with 150 M NaCl, 0.05 % NaN3 and 30 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C.

Referenzen für anti-Phospholamban Antikörper (ABIN285884)

Kushnir, Santulli, Reiken, Coromilas, Godfrey, Brunjes, Colombo, Yuzefpolskaya, Sokol, Kitsis, Marks: "Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure." in: Circulation, Vol. 138, Issue 11, pp. 1144-1154, (2019) (PubMed).

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: Phospholamban

Hintergrund: Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers.

Pathways: Negative Regulation of Transporter Activity