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MC1 Receptor Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MC1 Receptor in WB, IF, IHC (p), IHC (fro) und ICC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN2856574

Kurzübersicht für MC1 Receptor Antikörper (C-Term) (ABIN2856574)

Target

Alle MC1 Receptor (MC1R) Antikörper anzeigen
MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reaktivität

  • 65
  • 27
  • 11
  • 3
  • 3
  • 1
  • 1
Human

Wirt

  • 67
  • 10
Kaninchen

Klonalität

  • 72
  • 5
Polyklonal

Konjugat

  • 30
  • 8
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MC1 Receptor Antikörper ist unkonjugiert

Applikation

  • 53
  • 28
  • 26
  • 26
  • 14
  • 11
  • 8
  • 8
  • 7
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 16
    • 15
    • 11
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Rabbit Polyclonal antibody to MC1 Receptor (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor))
    MC1 Receptor antibody [C2C3], C-term

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MC1 Receptor. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.96 mg/mL

    Buffer

    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

    Andere Bezeichnung

    melanocortin 1 receptor

    Hintergrund

    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

    Cellular Localization: Cell membrane, Multi-pass membrane protein

    Molekulargewicht

    35 kDa

    Gen-ID

    4157

    UniProt

    Q01726

    Pathways

    cAMP Metabolic Process, Feeding Behaviour
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