IPO7 Antikörper (C-Term)

Produktnummer ABIN2856366

Dieses Anti-IPO7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IPO7 in WB, IHC (p), IF und ICC. Geeignet für Human.

Kurzübersicht für IPO7 Antikörper (C-Term) (ABIN2856366)

Target: IPO7 (Importin 7 (IPO7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IPO7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: KO Validated

Produktdetails anti-IPO7 Antikörper

Bindungsspezifität: C-Term

Spezifität: Knockdown/Knockout validation was supported by references (PMID:25999477)

Kreuzreaktivität: Human

Produktmerkmale: Rabbit Polyclonal antibody to Importin 7 (importin 7)
Importin 7 antibody [C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Importin 7. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu IPO7

Target: IPO7 (Importin 7 (IPO7))

Andere Bezeichnung: importin 7

Hintergrund: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Cellular Localization: Cytoplasm , Nucleus

Molekulargewicht: 120 kDa

Gen-ID: 10527

UniProt: O95373

Pathways: Protein targeting to Nucleus