GSTZ1 Antikörper
Kurzübersicht für GSTZ1 Antikörper (ABIN2856258)
Target
Alle GSTZ1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
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Kreuzreaktivität
- Human
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Produktmerkmale
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Rabbit Polyclonal antibody to GSTZ1 (glutathione transferase zeta 1)
GSTZ1 antibody [N1C3] -
Aufreinigung
- Purified by antigen-affinity chromatography.
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Immunogen
- Recombinant protein encompassing a sequence within the center region of human GSTZ1. The exact sequence is proprietary.
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Kommentare
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Positive Control: 293T
Validation: KO/KD, Orthogonal, Overexpression
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.98 mg/mL
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Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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Konservierungsmittel
- Thimerosal (Merthiolate)
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Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells." in: FEBS open bio, Vol. 10, Issue 1, pp. 6-17, (2020) (PubMed).
: "GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 438, (2020) (PubMed).
: "
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GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells." in: FEBS open bio, Vol. 10, Issue 1, pp. 6-17, (2020) (PubMed).
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- GSTZ1 (Glutathione Transferase zeta 1 (Maleylacetoacetate Isomerase) (GSTZ1))
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Andere Bezeichnung
- glutathione S-transferase zeta 1
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Hintergrund
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This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.
Cellular Localization: Cytoplasm -
Molekulargewicht
- 24 kDa
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Gen-ID
- 2954
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UniProt
- O43708
Target
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