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GSTZ1 Antikörper

Dieses Anti-GSTZ1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GSTZ1 in WB, IF, IHC (p) und ICC. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN2856258

Kurzübersicht für GSTZ1 Antikörper (ABIN2856258)

Target

Alle GSTZ1 Antikörper anzeigen
GSTZ1 (Glutathione Transferase zeta 1 (Maleylacetoacetate Isomerase) (GSTZ1))

Reaktivität

  • 23
  • 13
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 24
  • 5
Kaninchen

Klonalität

  • 26
  • 3
Polyklonal

Konjugat

  • 15
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GSTZ1 Antikörper ist unkonjugiert

Applikation

  • 29
  • 13
  • 13
  • 9
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Güteklasse

KO Validated
  • Kreuzreaktivität

    Human

    Produktmerkmale

    Rabbit Polyclonal antibody to GSTZ1 (glutathione transferase zeta 1)
    GSTZ1 antibody [N1C3]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human GSTZ1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: 293T

    Validation: KO/KD, Orthogonal, Overexpression

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.98 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Lei, Wang, Tang, Wang: "GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells." in: FEBS open bio, Vol. 10, Issue 1, pp. 6-17, (2020) (PubMed).

    Li, Wang, Yang, Lei, Yang, Liang, Chen, Xia, Wang, Tang: "GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 438, (2020) (PubMed).

  • Target

    GSTZ1 (Glutathione Transferase zeta 1 (Maleylacetoacetate Isomerase) (GSTZ1))

    Andere Bezeichnung

    glutathione S-transferase zeta 1

    Hintergrund

    This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.

    Cellular Localization: Cytoplasm

    Molekulargewicht

    24 kDa

    Gen-ID

    2954

    UniProt

    O43708
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