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CHFR Antikörper (C-Term)

Dieses Anti-CHFR-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHFR in WB. Geeignet für Human.
Produktnummer ABIN2855892

Kurzübersicht für CHFR Antikörper (C-Term) (ABIN2855892)

Target

Alle CHFR Antikörper anzeigen
CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

Reaktivität

  • 42
  • 15
  • 14
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 38
  • 3
  • 1
Kaninchen

Klonalität

  • 39
  • 3
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser CHFR Antikörper ist unkonjugiert

Applikation

  • 23
  • 22
  • 9
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Human

    Produktmerkmale

    Rabbit polyclonal antibody to CHFR (checkpoint with forkhead and ring finger domains)
    CHFR antibody [C3], C-term

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CHFR. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: H1299 , NT2D1

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

    Andere Bezeichnung

    checkpoint with forkhead and ring finger domains

    Hintergrund

    E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

    Cellular Localization: Nucleus

    Molekulargewicht

    73 kDa

    Gen-ID

    55743

    UniProt

    Q96EP1
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