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HSD11B1 Antikörper (C-Term)

Dieses Anti-HSD11B1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HSD11B1 in WB, ICC, IHC (p), IF und IHC (fro). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN2855871

Kurzübersicht für HSD11B1 Antikörper (C-Term) (ABIN2855871)

Target

Alle HSD11B1 Antikörper anzeigen
HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Reaktivität

  • 49
  • 26
  • 23
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 46
  • 8
  • 2
Kaninchen

Klonalität

  • 43
  • 13
Polyklonal

Konjugat

  • 35
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser HSD11B1 Antikörper ist unkonjugiert

Applikation

  • 33
  • 20
  • 17
  • 13
  • 8
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Human, Schaf

    Produktmerkmale

    Rabbit Polyclonal antibody to HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)
    HSD11B1 antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human HSD11B1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: HepG2

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Matsumura, Terao, Itami, Katayama: "Local cortisol activation is involved in EGF-induced immunosuppression." in: Dermato-endocrinology, Vol. 9, Issue 1, pp. e1412018, (2017) (PubMed).

  • Target

    HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

    Andere Bezeichnung

    hydroxysteroid 11-beta dehydrogenase 1

    Hintergrund

    The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

    Cellular Localization: Endoplasmic reticulum membrane

    Molekulargewicht

    32 kDa

    Gen-ID

    3290

    UniProt

    P28845

    Pathways

    Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process
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