HSD11B1 Antikörper (C-Term)
Kurzübersicht für HSD11B1 Antikörper (C-Term) (ABIN2855871)
Target
Alle HSD11B1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Kreuzreaktivität
- Human, Schaf
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Produktmerkmale
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Rabbit Polyclonal antibody to HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)
HSD11B1 antibody -
Aufreinigung
- Purified by antigen-affinity chromatography.
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Immunogen
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human HSD11B1. The exact sequence is proprietary.
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Kommentare
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Positive Control: HepG2
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal
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Konservierungsmittel
- Thimerosal (Merthiolate)
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Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Local cortisol activation is involved in EGF-induced immunosuppression." in: Dermato-endocrinology, Vol. 9, Issue 1, pp. e1412018, (2017) (PubMed).
: "
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Local cortisol activation is involved in EGF-induced immunosuppression." in: Dermato-endocrinology, Vol. 9, Issue 1, pp. e1412018, (2017) (PubMed).
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- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
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Andere Bezeichnung
- hydroxysteroid 11-beta dehydrogenase 1
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Hintergrund
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The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Cellular Localization: Endoplasmic reticulum membrane -
Molekulargewicht
- 32 kDa
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Gen-ID
- 3290
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UniProt
- P28845
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Pathways
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process
Target
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