PYGB Antikörper (C-Term)

Produktnummer ABIN2855804

Der Kaninchen Polyklonal Anti-PYGB-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, PYGB in Proben von Human und Maus zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PYGB Antikörper (C-Term) (ABIN2855804)

Target: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYGB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PYGB Antikörper

Bindungsspezifität: C-Term

Produktmerkmale: Rabbit Polyclonal antibody to GPBB (phosphorylase, glycogen, brain)
GPBB antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human GPBB. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: HepG2 , mouse brain

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.84 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-PYGB Antikörper (ABIN2855804)

Cooper, Pasini, Lambert, DAlessandro, Yao, Risner, Calkins: "Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18810-18821, (2020) (PubMed).

Geiszler, Ugun-Klusek, Lawler, Pardon, Yuchun, Bai, Daykin, Auer, Bedford: "Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons." in: Scientific reports, Vol. 8, Issue 1, pp. 4833, (2019) (PubMed).

Details zu PYGB

Target: PYGB (GPBB) (phosphorylase, Glycogen, Brain (GPBB))

Andere Bezeichnung: GPBB

Hintergrund: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Molekulargewicht: 97 kDa

Gen-ID: 5834

Pathways: Cellular Glucan Metabolic Process