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HPD Antikörper

Der Kaninchen Polyklonal Anti-HPD-Antikörper wurde für WB validiert. Er ist geeignet, HPD in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2855744

Kurzübersicht für HPD Antikörper (ABIN2855744)

Target

Alle HPD Antikörper anzeigen
HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))

Reaktivität

  • 80
  • 30
  • 13
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 72
  • 17
Kaninchen

Klonalität

  • 70
  • 19
Polyklonal

Konjugat

  • 43
  • 8
  • 8
  • 8
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
Dieser HPD Antikörper ist unkonjugiert

Applikation

  • 55
  • 37
  • 30
  • 16
  • 14
  • 6
  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)

Güteklasse

KO Validated
  • Kreuzreaktivität

    Human

    Produktmerkmale

    Rabbit polyclonal antibody to HPD (4-hydroxyphenylpyruvate dioxygenase)
    HPD antibody [N1C2]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human HPD. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: HepG2

    Validation: KO/KD

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Shan, Lu, Li, Sheng, Fan, Qi, Liu, Zhang: "4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis." in: Cell death & disease, Vol. 10, Issue 7, pp. 525, (2020) (PubMed).

  • Target

    HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))

    Andere Bezeichnung

    4-hydroxyphenylpyruvate dioxygenase

    Hintergrund

    The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.

    Molekulargewicht

    45 kDa

    Gen-ID

    3242

    UniProt

    P32754
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