NOX1 Antikörper

Produktnummer ABIN2855720

Der Kaninchen Polyklonal Anti-NOX1-Antikörper wurde für WB, ICC, IHC (p) und IF validiert. Er ist geeignet, NOX1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für NOX1 Antikörper (ABIN2855720)

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-NOX1 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to NOX1 (NADPH oxidase 1)
NOX1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human NOX1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: JC , BCL-1 , 293T , A431 , HeLa

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.19 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-NOX1 Antikörper (ABIN2855720)

Liang, Ma, Zhong, Dhar, Liu, Xu, Koyama, Nishio, Karin, Karin, Mccubbin, Zhang, Hu, Yang, Chen, Ganguly, Lan, Karin, Kisseleva, Brenner: "NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice." in: Gastroenterology, Vol. 156, Issue 4, pp. 1156-1172.e6, (2019) (PubMed).

Sandrini, Ieraci, Amadio, Popoli, Tremoli, Barbieri: "Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 9258937, (2018) (PubMed).

Details zu NOX1

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Andere Bezeichnung: NADPH oxidase 1

Hintergrund: Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Membrane, Multi-pass membrane protein

Molekulargewicht: 65 kDa

Gen-ID: 27035

UniProt: Q9Y5S8

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport