Exportin 2 Antikörper (Center)

Produktnummer ABIN2855534

Der Kaninchen Polyklonal Anti-Exportin 2-Antikörper wurde für WB, IF, IP, IHC (p) und ICC validiert. Er ist geeignet, Exportin 2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Exportin 2 Antikörper (Center) (ABIN2855534)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Exportin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Produktdetails anti-Exportin 2 Antikörper

Bindungsspezifität: Center

Kreuzreaktivität: Schwein, Rhesusaffen, Rind (Kuh)

Kreuzreaktivität (Details): Pig (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Produktmerkmale: Rabbit Polyclonal antibody to CSE1L (CSE1 chromosome segregation 1-like (yeast))
CSE1L antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CSE1L. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation Assay-dependent dilution Western blot 1:500-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* ImmunoprecipitationAssay-dependent dilution Western blot1:500-1:10000*

Kommentare:

Positive Control: NIH-3T3 , JC , BCL-1 , C2C12 , 293T , A431 , HeLa , HepG2 , A375 , PC-12 , Rat2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.71 mg/mL

Buffer: 1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Andere Bezeichnung: CSE1L

Hintergrund: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Cellular Localization: Cytoplasm , Nucleus

Molekulargewicht: 110 kDa

Gen-ID: 1434

Pathways: Protein targeting to Nucleus