Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (C-Term) Antikörper

CBLB Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855378
  • Target Alle Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antikörper anzeigen
    Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 34
    • 26
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 47
    • 2
    Kaninchen
    Klonalität
    • 47
    • 2
    Polyklonal
    Konjugat
    • 17
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 41
    • 20
    • 13
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Rind (Kuh)
    Kreuzreaktivität (Details)
    Bovine (95 %)
    Produktmerkmale
    Rabbit polyclonal antibody to CBL-B (Cas-Br-M (murine) ecotropic retroviral transforming sequence b)
    Cbl-b antibody [C2C3], C-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human Cbl-b. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product CBLB Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*
    Kommentare

    Positive Control: HepG2

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.72 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
    Andere Bezeichnung
    CBL-B (CBLB Produkte)
    Synonyme
    rnf56 antikoerper, cblb antikoerper, AI429560 antikoerper, AI851073 antikoerper, Cbl-b antikoerper, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antikoerper, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antikoerper, Casitas B-lineage lymphoma b antikoerper, Cbl proto-oncogene B antikoerper, cblb.S antikoerper, cblb.L antikoerper, Cblb antikoerper, CBLB antikoerper
    Hintergrund
    E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.

    Cellular Localization: Cytoplasm
    Molekulargewicht
    109 kDa
    Gen-ID
    868
Sie sind hier:
Kundenservice