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HYOU1 Antikörper (C-Term)

HYOU1 Reaktivität: Human WB, IF, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855339
  • Target Alle HYOU1 Antikörper anzeigen
    HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
    Bindungsspezifität
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 72
    • 27
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 30
    Kaninchen
    Klonalität
    • 38
    • 36
    Polyklonal
    Konjugat
    • 27
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HYOU1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 26
    • 23
    • 14
    • 14
    • 13
    • 13
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Pflanzen, Ratte
    Produktmerkmale
    Rabbit Polyclonal antibody to ORP150 (hypoxia up-regulated 1)
    ORP150 antibody [C2C3], C-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human ORP150. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product HYOU1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: mouse liver , rat brain , MCF-7 , MDA-MB-231

    Validation: Orthogonal

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.41 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
    Andere Bezeichnung
    hypoxia up-regulated 1 (HYOU1 Produkte)
    Synonyme
    GRP-170 antikoerper, Grp170 antikoerper, HSP12A antikoerper, ORP-150 antikoerper, ORP150 antikoerper, AI415631 antikoerper, CBP-140 antikoerper, Cab140 antikoerper, Orp150 antikoerper, id:ibd5056 antikoerper, wu:fd14c05 antikoerper, zgc:56019 antikoerper, HYOU1 antikoerper, orp150 antikoerper, GRP170 antikoerper, hypoxia up-regulated 1 antikoerper, hypoxia up-regulated protein 1 antikoerper, hypoxia up-regulated 1 S homeolog antikoerper, HYOU1 antikoerper, Hyou1 antikoerper, hyou1 antikoerper, LOC100380749 antikoerper, hyou1.S antikoerper
    Hintergrund
    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

    Cellular Localization: Endoplasmic reticulum lumen
    Molekulargewicht
    111 kDa
    Gen-ID
    10525
    UniProt
    Q9Y4L1
    Pathways
    ER-Nucleus Signaling, SARS-CoV-2 Protein Interaktom
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