POM121 Antikörper (N-Term)

Produktnummer ABIN2855297

Der Kaninchen Polyklonal Anti-POM121-Antikörper wurde für WB, IF, IHC (p) und ICC validiert. Er ist geeignet, POM121 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für POM121 Antikörper (N-Term) (ABIN2855297)

Target: POM121 (POM121 Membrane Glycoprotein (POM121))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POM121 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Produktdetails anti-POM121 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to POM121 (POM121 membrane glycoprotein (rat))
POM121 antibody [N2N3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human POM121. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A549

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.16 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-POM121 Antikörper (ABIN2855297)

Ma, Li, Jia, Gong, Wang, Zhang, Gu, Tang: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." in: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).

Rodriguez-Bravo, Pippa, Song, Carceles-Cordon, Dominguez-Andres, Fujiwara, Woo, Koh, Ertel, Lokareddy, Cuesta-Dominguez, Kim, Rodriguez-Fernandez, Li, Gordon, Hirschfield, Prats, Reddy, Fatatis et al.: "Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. ..." in: Cell, Vol. 174, Issue 5, pp. 1200-1215.e20, (2019) (PubMed).

Jiang, Gan, Yen, Moussaud, McLean, Dickson: "Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons." in: Acta neuropathologica, Vol. 132, Issue 1, pp. 77-91, (2017) (PubMed).

Schwartz, Travesa, Martell, Forbes: "Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin." in: Nucleus (Austin, Tex.), Vol. 6, Issue 1, pp. 40-54, (2015) (PubMed).

Chow, Elgort, Dasso, Powers, Ullman: "The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function." in: Molecular biology of the cell, Vol. 25, Issue 1, pp. 160-8, (2014) (PubMed).

Details zu POM121

Target: POM121 (POM121 Membrane Glycoprotein (POM121))

Andere Bezeichnung: POM121 transmembrane nucleoporin

Hintergrund: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Single-pass membrane protein , Endoplasmic reticulum membrane, Single-pass membrane protein (By similarity)

Molekulargewicht: 128 kDa

Gen-ID: 9883

UniProt: Q96HA1