ADAMTSL2 Antikörper (C-Term)

Produktnummer ABIN2855279

Der Kaninchen Polyklonal Anti-ADAMTSL2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, ADAMTSL2 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für ADAMTSL2 Antikörper (C-Term) (ABIN2855279)

Target: ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAMTSL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ADAMTSL2 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to ADAMTSL2 (ADAMTS-like 2)
ADAMTSL2 antibody [C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ADAMTSL2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: H1299

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-ADAMTSL2 Antikörper (ABIN2855279)

Piccolo, Sabatino, Mithbaokar, Polishchuck, Law, Magraner-Pardo, Pons, Polishchuck, Brunetti-Pierri: "Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking." in: Molecular genetics and metabolism reports, Vol. 21, pp. 100504, (2019) (PubMed).

Aviram, Zaffryar-Eilot, Hubmacher, Grunwald, Mäki, Myllyharju, Apte, Hasson: "Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 75-76, pp. 114-125, (2019) (PubMed).

Details zu ADAMTSL2

Target: ADAMTSL2 (ADAMTS-Like 2 (ADAMTSL2))

Andere Bezeichnung: ADAMTS like 2

Hintergrund: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix, it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia.

Cellular Localization: Secreted

Molekulargewicht: 105 kDa

Gen-ID: 9719

UniProt: Q86TH1