ACTC1 Antikörper

Produktnummer ABIN2855212

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACTC1 in WB, ICC, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für ACTC1 Antikörper (ABIN2855212)

Target: ACTC1 (Actin, Alpha, Cardiac Muscle 1 (ACTC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-ACTC1 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to alpha Cardiac Muscle Actin (actin, alpha, cardiac muscle 1)
alpha Cardiac Muscle Actin antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human alpha Cardiac Muscle Actin. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: PC-12 , Rat2 , Jurkat , Raji , K562 , THP-1 , NIH-3T3 , JC , BCL-1 , Rat muscle

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.56 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-ACTC1 Antikörper (ABIN2855212)

Henry, Szabó, Sutus, Pirity: "RYBP is important for cardiac progenitor cell development and sarcomere formation." in: PLoS ONE, Vol. 15, Issue 7, pp. e0235922, (2020) (PubMed).

Oldershaw, Owens, Sutherland, Linney, Liddle, Magana, Lash, Gill, Richardson, Meeson: "Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential." in: Stem cells and development, Vol. 28, Issue 9, pp. 593-607, (2020) (PubMed).

Miksiunas, Rucinskas, Janusauskas, Labeit, Bironaite: "Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells." in: International journal of molecular sciences, Vol. 21, Issue 14, (2020) (PubMed).

Robertson, Wen, Yin, Chen, Smith, Paine: "Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells." in: Frontiers in physiology, Vol. 8, pp. 336, (2017) (PubMed).

Details zu ACTC1

Target: ACTC1 (Actin, Alpha, Cardiac Muscle 1 (ACTC1))

Andere Bezeichnung: actin alpha cardiac muscle 1

Hintergrund: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Cellular Localization: Cytoplasm , cytoskeleton

Molekulargewicht: 42 kDa

Gen-ID: 70

UniProt: P68032

Pathways: Myometrial Relaxation and Contraction