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Factor VII Antikörper

Dieses Anti-Factor VII-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Factor VII in WB und IHC (p). Geeignet für Human.
Produktnummer ABIN2854983

Kurzübersicht für Factor VII Antikörper (ABIN2854983)

Target

Alle Factor VII (F7) Antikörper anzeigen
Factor VII (F7) (Coagulation Factor VII (F7))

Reaktivität

  • 58
  • 14
  • 10
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 58
  • 12
  • 8
  • 2
  • 1
Kaninchen

Klonalität

  • 70
  • 11
Polyklonal

Konjugat

  • 52
  • 18
  • 4
  • 3
  • 2
  • 1
  • 1
Dieser Factor VII Antikörper ist unkonjugiert

Applikation

  • 64
  • 34
  • 24
  • 23
  • 19
  • 7
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Spezifität

    Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.

    Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))
    Factor VII antibody [N3C3]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: NIH-3T3

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    2.32 mg/mL

    Buffer

    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Factor VII (F7) (Coagulation Factor VII (F7))

    Andere Bezeichnung

    coagulation factor VII

    Hintergrund

    This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.

    Cellular Localization: Secreted

    Molekulargewicht

    52 kDa

    Gen-ID

    2155

    UniProt

    P08709

    Pathways

    Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling
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