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COMT Antikörper

Dieses Anti-COMT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von COMT in WB, ELISA und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN2854980

Kurzübersicht für COMT Antikörper (ABIN2854980)

Target

Alle COMT Antikörper anzeigen
COMT (Catechol-O-Methyltransferase (COMT))

Reaktivität

  • 60
  • 50
  • 42
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 70
  • 23
  • 3
  • 1
Kaninchen

Klonalität

  • 66
  • 31
Polyklonal

Konjugat

  • 65
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser COMT Antikörper ist unkonjugiert

Applikation

  • 62
  • 42
  • 29
  • 26
  • 23
  • 13
  • 13
  • 10
  • 7
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse

KO Validated
  • Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Rabbit Polyclonal antibody to COMT (catechol-O-methyltransferase)
    COMT antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human COMT. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. ELISA: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: mouse spleen , Molt-4 , 293T

    Validation: KO/KD

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.32 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ikeda, Iijima, Shinoda, Iwamoto, Takeda: "Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase." in: Molecules (Basel, Switzerland), Vol. 22, Issue 8, (2018) (PubMed).

  • Target

    COMT (Catechol-O-Methyltransferase (COMT))

    Andere Bezeichnung

    catechol-O-methyltransferase

    Hintergrund

    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

    Cellular Localization: Isoform Soluble: Cytoplasm , Isoform Membrane-bound: Cell membrane

    Molekulargewicht

    30 kDa

    Gen-ID

    1312

    UniProt

    P21964

    Pathways

    Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interaktom
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