FLNB Antikörper (N-Term)

Produktnummer ABIN2854971

Dieses Anti-FLNB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FLNB in WB, IF, ICC und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für FLNB Antikörper (N-Term) (ABIN2854971)

Target: FLNB (Filamin B, beta (FLNB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLNB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: KO Validated

Produktdetails anti-FLNB Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to Filamin B (filamin B, beta)
Filamin B antibody [N1], N-term

Aufreinigung: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Filamin B. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: U87-MG , NIH-3T3 , 293T , A431 , HeLa , HepG2

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 10 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-FLNB Antikörper (ABIN2854971)

Artym, Swatkoski, Matsumoto, Campbell, Petrie, Dimitriadis, Li, Mueller, Bugge, Gucek, Yamada: "Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network." in: The Journal of cell biology, Vol. 208, Issue 3, pp. 331-50, (2015) (PubMed).

Details zu FLNB

Target: FLNB (Filamin B, beta (FLNB))

Andere Bezeichnung: filamin B

Hintergrund: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome, and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Cellular Localization: Isoform 1: Cytoplasm , cell cortex , Cytoplasm , cytoskeleton , myofibril , sarcomere , Z-disk , Isoform 2: Cytoplasm , Isoform 3: Cytoplasm , Isoform 6: Cytoplasm

Molekulargewicht: 278 kDa

Gen-ID: 2317

UniProt: O75369

Pathways: Maintenance of Protein Location