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BMP4 Antikörper

Der Kaninchen Polyklonal Anti-BMP4-Antikörper wurde für WB, ICC, IF und IHC (p) validiert. Er ist geeignet, BMP4 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN2854883

Kurzübersicht für BMP4 Antikörper (ABIN2854883)

Target

Alle BMP4 Antikörper anzeigen
BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reaktivität

  • 72
  • 45
  • 40
  • 20
  • 16
  • 13
  • 8
  • 8
  • 7
  • 6
  • 6
  • 3
  • 3
  • 2
  • 1
Human

Wirt

  • 120
  • 25
  • 11
  • 1
  • 1
Kaninchen

Klonalität

  • 128
  • 30
Polyklonal

Konjugat

  • 87
  • 27
  • 13
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BMP4 Antikörper ist unkonjugiert

Applikation

  • 136
  • 78
  • 57
  • 42
  • 40
  • 14
  • 13
  • 6
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Spezifität

    This antibody is able to recognize full length BMP4 protein (~55 kDa) and N-terminal propeptide BMP4 protein (~40 kDa) but unable to detect mature form.

    Kreuzreaktivität

    Human, Maus

    Produktmerkmale

    Rabbit Polyclonal antibody to BMP4 (bone morphogenetic protein 4)
    BMP4 antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human BMP4. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: NIH-3T3 , JC , HepG2 conditioned medium

    Validation: Orthogonal

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.36 mg/mL

    Buffer

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Guo, Wang, Yuan, Zhu, Fu, Xu, Wu, Wu: "TSA restores hair follicle-inductive capacity of skin-derived precursors." in: Scientific reports, Vol. 9, Issue 1, pp. 2867, (2020) (PubMed).

    Peng, Chen, Wang, Zhu, Wu, Luo, Zuo, Luo, Zhou, Shi, Weng, Huang, He, Fan: "Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes." in: Aging, Vol. 11, Issue 23, pp. 11520-11540, (2019) (PubMed).

  • Target

    BMP4 (Bone Morphogenetic Protein 4 (BMP4))

    Andere Bezeichnung

    bone morphogenetic protein 4

    Hintergrund

    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

    Cellular Localization: Secreted , extracellular space , extracellular matrix

    Molekulargewicht

    47 kDa

    Gen-ID

    652

    UniProt

    P12644

    Pathways

    Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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