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Granulin Antikörper (Center)

Der Kaninchen Polyklonal Anti-Granulin-Antikörper wurde für WB, ICC, IF und IHC (p) validiert. Er ist geeignet, Granulin in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN2854868

Kurzübersicht für Granulin Antikörper (Center) (ABIN2854868)

Target

Alle Granulin (GRN) Antikörper anzeigen
Granulin (GRN)

Reaktivität

  • 58
  • 11
  • 5
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 52
  • 11
  • 5
  • 2
  • 1
Kaninchen

Klonalität

  • 57
  • 14
Polyklonal

Konjugat

  • 46
  • 7
  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Granulin Antikörper ist unkonjugiert

Applikation

  • 64
  • 30
  • 20
  • 19
  • 18
  • 13
  • 13
  • 6
  • 6
  • 3
  • 3
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center

    Produktmerkmale

    Rabbit Polyclonal antibody to Granulins (granulin)
    Granulins antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human Granulins. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

    Kommentare

    Positive Control: HepG2 , mouse kidney , rat kidney

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.48 mg/mL

    Buffer

    1XPBS, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Granulin (GRN)

    Andere Bezeichnung

    Granulins

    Hintergrund

    Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

    Cellular Localization: Secreted

    Molekulargewicht

    64 kDa

    Gen-ID

    2896
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