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ACSL4 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACSL4 in WB, IF, ICC, IHC (p) und IP. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN2854678

Kurzübersicht für ACSL4 Antikörper (C-Term) (ABIN2854678)

Target

Alle ACSL4 Antikörper anzeigen
ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))

Reaktivität

  • 71
  • 26
  • 24
  • 4
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 70
  • 3
  • 1
Kaninchen

Klonalität

  • 65
  • 9
Polyklonal

Konjugat

  • 40
  • 5
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ACSL4 Antikörper ist unkonjugiert

Applikation

  • 63
  • 28
  • 26
  • 21
  • 16
  • 10
  • 8
  • 5
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
  • Bindungsspezifität

    • 10
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Rabbit Polyclonal antibody to FACL4 (acyl-CoA synthetase long-chain family member 4)
    FACL4 antibody [C3], C-term

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FACL4. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:1000-1:5000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.44 mg/mL

    Buffer

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Ndiaye, Liu, Hall, Minogue, Morgan, Waugh: "Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases." in: Bioscience reports, Vol. 40, Issue 4, (2020) (PubMed).

    Garcia-Bermudez, Baudrier, Bayraktar, Shen, La, Guarecuco, Yucel, Fiore, Tavora, Freinkman, Chan, Lewis, Min, Inghirami, Sabatini, Birsoy: "Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death." in: Nature, Vol. 567, Issue 7746, pp. 118-122, (2019) (PubMed).

    Radif, Ndiaye, Kalantzi, Jacobs, Hall, Minogue, Waugh: "The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells." in: Molecular and cellular biochemistry, Vol. 448, Issue 1-2, pp. 275-286, (2018) (PubMed).

  • Target

    ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))

    Andere Bezeichnung

    acyl-CoA synthetase long chain family member 4

    Hintergrund

    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

    Cellular Localization: Mitochondrion outer membrane, Single-pass type III membrane protein , Peroxisome membrane, Single-pass type III membrane protein , Microsome membrane, Single-pass type III membrane protein , Endoplasmic reticulum membrane, Single-pass type III membrane pr

    Molekulargewicht

    79 kDa

    Gen-ID

    2182

    UniProt

    O60488
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