Aconitase 1 Antikörper
Kurzübersicht für Aconitase 1 Antikörper (ABIN2854415)
Target
Alle Aconitase 1 (ACO1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Kreuzreaktivität
- Human
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Produktmerkmale
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Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)
Aconitase 1 antibody [N1C1] -
Aufreinigung
- Purified by antigen-affinity chromatography.
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Immunogen
- Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Kommentare
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Positive Control: A431 , HeLa , HepG2
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.78 mg/mL
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Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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Konservierungsmittel
- Thimerosal (Merthiolate)
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Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Aconitase 1 (ACO1)
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Andere Bezeichnung
- aconitase 1
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Hintergrund
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Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Cellular Localization: Cytoplasm -
Molekulargewicht
- 98 kDa
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Gen-ID
- 48
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UniProt
- P21399
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Pathways
- Transition Metal Ion Homeostasis
Target
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