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Aconitase 1 Antikörper

Der Kaninchen Polyklonal Anti-Aconitase 1-Antikörper wurde für WB, ICC und IF validiert. Er ist geeignet, Aconitase 1 in Proben von Human zu detektieren.
Produktnummer ABIN2854415

Kurzübersicht für Aconitase 1 Antikörper (ABIN2854415)

Target

Alle Aconitase 1 (ACO1) Antikörper anzeigen
Aconitase 1 (ACO1)

Reaktivität

  • 108
  • 54
  • 46
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 119
  • 4
  • 1
Kaninchen

Klonalität

  • 119
  • 5
Polyklonal

Konjugat

  • 58
  • 14
  • 8
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Aconitase 1 Antikörper ist unkonjugiert

Applikation

  • 108
  • 39
  • 35
  • 33
  • 26
  • 25
  • 21
  • 16
  • 11
  • 10
  • 7
  • 3
  • 2
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Kreuzreaktivität

    Human

    Produktmerkmale

    Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)
    Aconitase 1 antibody [N1C1]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: A431 , HeLa , HepG2

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.78 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Aconitase 1 (ACO1)

    Andere Bezeichnung

    aconitase 1

    Hintergrund

    Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

    Cellular Localization: Cytoplasm

    Molekulargewicht

    98 kDa

    Gen-ID

    48

    UniProt

    P21399

    Pathways

    Transition Metal Ion Homeostasis
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