RAP1A Antikörper (Center)

Produktnummer ABIN2854404

Dieses Anti-RAP1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RAP1A in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für RAP1A Antikörper (Center) (ABIN2854404)

Target: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RAP1A Antikörper

Bindungsspezifität: Center

Kreuzreaktivität: Maus, Ratte (Rattus), Rhesusaffen, Rind (Kuh)

Kreuzreaktivität (Details): Mouse (100 %), Rat (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Produktmerkmale: Rabbit polyclonal antibody to RAP1A (RAP1A, member of RAS oncogene family)
RAP1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human RAP1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Kommentare:

Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.53 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-RAP1A Antikörper (ABIN2854404)

Chinigò, Grolez, Audero, Bokhobza, Bernardini, Cicero, Toillon, Bailleul, Visentin, Ruffinatti, Brysbaert, Lensink, De Ruyck, Cantelmo, Fiorio Pla, Gkika: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." in: Cancers, Vol. 14, Issue 9, (2022) (PubMed).

Details zu RAP1A

Target: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Andere Bezeichnung: RAP1

Hintergrund: The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50 % amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

Cellular Localization: Cell membrane, Lipid-anchor

Molekulargewicht: 21 kDa

Gen-ID: 5906

Pathways: T-Zell Rezeptor Signalweg, Neurotrophin Signalübertragung, Signaling of Hepatocyte Growth Factor Receptor