Der Kaninchen Polyklonal anti-Protease Antikörper (ABIN284976) detektiert spezifisch Protease in ELISA und WB.
Dieser Antikörper reagiert spezifisch mit Proben aus Human Immunodeficiency Virus (HIV).
ELISA: 1:500-1:1,000, WB: 1:500-1:1,000 Optimal conditions should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Frozen
Konzentration
Lot specific
Buffer
Supplied frozen in PBS.
Handhabung
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -70 °C for long term storage.
Target
Protease
Substanzklasse
Viral Protein
Hintergrund
HIV-1 protease (HIV PR) is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV PR cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV PR, HIV virions remain uninfectious. Thus, mutation of HIV PR’s active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells, making HIV PR inhibition the subject of much pharmaceutical research.