CASC3 Antikörper (AA 501-600) (AbBy Fluor® 594)

Produktnummer ABIN2811115

Der Kaninchen Polyklonal Anti-CASC3-Antikörper wurde für WB, IF (p) und IF (cc) validiert. Er ist geeignet, CASC3 in Proben von Maus zu detektieren.

Kurzübersicht für CASC3 Antikörper (AA 501-600) (AbBy Fluor® 594) (ABIN2811115)

Target: CASC3 (Cancer Susceptibility Candidate 3 (CASC3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASC3 Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-CASC3 Antikörper (AbBy Fluor® 594)

Bindungsspezifität: AA 501-600

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CASC3/MLN51

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CASC3

Target: CASC3 (Cancer Susceptibility Candidate 3 (CASC3))

Andere Bezeichnung: CASC3

Hintergrund:

Synonyms: Barentsz protein, Btz, Cancer susceptibility candidate gene 3 protein, Metastatic lymph node protein 51, MLN 51 protein, MLN51, Protein barentsz, Protein CASC3, Protein MLN 51, MLN51, CASC3_HUMAN.

Background: The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

Gen-ID: 22794