Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

UNC5B Antikörper (AA 188-260) (AbBy Fluor® 594)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UNC5B in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN2807394

Kurzübersicht für UNC5B Antikörper (AA 188-260) (AbBy Fluor® 594) (ABIN2807394)

Target

Alle UNC5B Antikörper anzeigen
UNC5B (Netrin receptor UNC5B (UNC5B))

Reaktivität

  • 36
  • 27
  • 21
  • 3
  • 3
Human, Maus, Ratte

Wirt

  • 33
  • 3
  • 2
Kaninchen

Klonalität

  • 36
  • 2
Polyklonal

Konjugat

  • 11
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UNC5B Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation

  • 26
  • 14
  • 12
  • 12
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 188-260

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Dog,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human UNC5B

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    UNC5B (Netrin receptor UNC5B (UNC5B))

    Andere Bezeichnung

    UNC5B/UNC5H2

    Hintergrund

    Synonyms: Netrin receptor UNC5B, Netrin receptor UNC5B Precursor, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Protein XUNC 5, Transmembrane receptor Unc5H2, Unc 5 homolog 2, Unc 5 homolog B, UNC 5B, Unc5 C.elegans homolog b, Unc5b, UNC5B_HUMAN, UNC5H2.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.

Sie sind hier:
Chat with us!