RECQL5 Antikörper (AA 1-100) (AbBy Fluor® 594)

Produktnummer ABIN2805876

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RECQL5 in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RECQL5 Antikörper (AA 1-100) (AbBy Fluor® 594) (ABIN2805876)

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RECQL5 Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-RECQL5 Antikörper (AbBy Fluor® 594)

Bindungsspezifität: AA 1-100

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RECQL5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RECQL5

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Andere Bezeichnung: RECQL5

Hintergrund:

Synonyms: ATP-dependent DNA helicase Q5, DNA helicase, RecQ like type 5, DNA helicase, RECQ-like, type 5, RecQ helicase protein-like 5 beta, RecQ protein-like 5, RecQ protein-like 5, isoform CRA_b, RecQ5, Recq5b, Recql5b.

Background: RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.