Prostacyclin Receptor Antikörper (AA 101-200) (AbBy Fluor® 594)

Produktnummer ABIN2805608

Dieses Anti-Prostacyclin Receptor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Prostacyclin Receptor in IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für Prostacyclin Receptor Antikörper (AA 101-200) (AbBy Fluor® 594) (ABIN2805608)

Target: Prostacyclin Receptor (PTGIR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prostacyclin Receptor Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Prostacyclin Receptor Antikörper (AbBy Fluor® 594)

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Prostaglandin I2 Receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Prostacyclin Receptor

Target: Prostacyclin Receptor (PTGIR)

Andere Bezeichnung: Prostaglandin I2 Receptor

Hintergrund:

Synonyms: IP, PGI receptor, PGI2 receptor, PI2R_HUMAN, PRIPR, Prostacyclin receptor, Prostaglandin I2 receptor, Prostanoid IP receptor, PTGIR.

Background: Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.

Pathways: cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling