CBP Antikörper (AbBy Fluor® 594)

Produktnummer ABIN2803505

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CBP in IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CBP Antikörper (AbBy Fluor® 594) (ABIN2803505)

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBP Antikörper ist konjugiert mit AbBy Fluor® 594

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-CBP Antikörper (AbBy Fluor® 594)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KAT3A/CBP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Andere Bezeichnung: KAT3A/ CBP

Hintergrund:

Synonyms: CBP, CBP/p300, CBP_HUMAN, CREB binding protein, CREB-binding protein, CREBBP, Cyclic AMP responsive enhancer binding protein, Cyclic AMP-responsive enhancer binding protein, KAT3A, RSTS, RTS, Rubinstein Taybi syndrome, Rubinstein-Taybi syndrome.

Background: Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 Molecules lacking an intact E1A binding site bypass E1A repression, even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.

Gen-ID: 1387

Pathways: T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha