BAG4 Antikörper (C-Term)

Produktnummer ABIN2799014

Der Kaninchen Polyklonal Anti-BAG4-Antikörper wurde für WB validiert. Er ist geeignet, BAG4 in Proben von Human zu detektieren.

Kurzübersicht für BAG4 Antikörper (C-Term) (ABIN2799014)

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BAG4 Antikörper

Bindungsspezifität: AA 381-409, C-Term

Verwendungszweck: Rabbit Anti-Human BAG4 (C-term) Antibody

Immunogen: This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000BAG4 Antibody (C-term) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Andere Bezeichnung: BAG4

Hintergrund:

Target Description: BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

Gene Symbol: BAG4

Molekulargewicht: 49594 Da

Gen-ID: 9530

UniProt: O95429

Pathways: Regulation of Actin Filament Polymerization