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SIGLEC11 Antikörper (C-Term)

SIGLEC11 Reaktivität: Human IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2799004
  • Target Alle SIGLEC11 Antikörper anzeigen
    SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))
    Bindungsspezifität
    • 15
    • 7
    • 6
    AA 631-662, C-Term
    Reaktivität
    Human
    Wirt
    • 28
    • 1
    • 1
    Kaninchen
    Klonalität
    • 29
    • 1
    Polyklonal
    Konjugat
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC11 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 16
    • 13
    • 13
    • 12
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Verwendungszweck
    Rabbit Anti-Human SIGLEC11 (C-term) Antibody
    Immunogen
    This SIGLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-662 amino acids from the C-terminal region of human SIGLEC11.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SIGLEC11 Primärantikörper
  • Applikationshinweise
    Western Blot, Immunohistochemistry
    Recommended Dilutions
    WB: 1:1000, IHC: 1:10-50SIGLEC11 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.310 mg/mL
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    2-8°C (short-term), -20°C (long-term)
  • Target
    SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))
    Andere Bezeichnung
    SIGLEC11 (SIGLEC11 Produkte)
    Synonyme
    sialic acid binding Ig like lectin 11 antikoerper, SIGLEC11 antikoerper
    Hintergrund

    Target Description: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.

    Gene Symbol: SIGLEC11

    Molekulargewicht
    75795 Da
    Gen-ID
    114132
    UniProt
    Q96RL6
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