SIGLEC11 Antikörper (C-Term)

Produktnummer ABIN2799004

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIGLEC11 in IHC und WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SIGLEC11 Antikörper (C-Term) (ABIN2799004)

Target: SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC11 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-SIGLEC11 Antikörper

Bindungsspezifität: AA 631-662, C-Term

Verwendungszweck: Rabbit Anti-Human SIGLEC11 (C-term) Antibody

Immunogen: This SIGLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-662 amino acids from the C-terminal region of human SIGLEC11.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50SIGLEC11 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.310 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu SIGLEC11

Target: SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11 (SIGLEC11))

Andere Bezeichnung: SIGLEC11

Hintergrund:

Target Description: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.

Gene Symbol: SIGLEC11

Molekulargewicht: 75795 Da

Gen-ID: 114132

UniProt: Q96RL6