KIDINS220 Antikörper (C-Term)

Produktnummer ABIN2798982

Der Kaninchen Polyklonal anti-KIDINS220 Antikörper (ABIN2798982) detektiert spezifisch KIDINS220 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KIDINS220 Antikörper (C-Term) (ABIN2798982)

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIDINS220 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIDINS220 Antikörper

Bindungsspezifität: AA 1518-1547, C-Term

Verwendungszweck: Rabbit Anti-Human KIDINS220 (C-term) Antibody

Immunogen: This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000KIDINS220 Antibody (C-term) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Andere Bezeichnung: KIDINS220

Hintergrund:

Target Description: KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Gene Symbol: KIDINS220

Molekulargewicht: 196542 Da

Gen-ID: 57498

UniProt: Q9ULH0