SIGLEC6 Antikörper (N-Term)

Produktnummer ABIN2798979

Dieses Anti-SIGLEC6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIGLEC6 in WB. Geeignet für Human.

Kurzübersicht für SIGLEC6 Antikörper (N-Term) (ABIN2798979)

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SIGLEC6 Antikörper

Bindungsspezifität: AA 10-40, N-Term

Verwendungszweck: Rabbit Anti-Human SIGLEC6 (N-term) Antibody

Immunogen: This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of human SIGLEC6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of SIGLEC6 Antibody (N-term) was detected using the purified Pab.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.0 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu SIGLEC6

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Andere Bezeichnung: SIGLEC6

Hintergrund:

Target Description: SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Gene Symbol: SIGLEC6

Molekulargewicht: 49913 Da

Gen-ID: 946

UniProt: O43699